REVRS Science & Clinical Studies

Want to geek out on the science?

REVRS is powered by scientifically backed ingredients like NMNH, Deazaflavin Pro, Ergothioneine, and AC-11®. These patented and clinically studied compounds support cellular repair, mitochondrial health, antioxidant defense, and DNA repair.

Below is a collection of published studies, patents, and supporting documents affiliates can reference when asked about the science behind REVRS.

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Highlighted Studies & Research

Deazaflavin (TND1128) & Cellular Energy

• TND1128, a 5-deazaflavin derivative with auto-redox ability, facilitates polarization of mitochondrial membrane potential (ΔΨm) and on-demand ATP synthesis in mice brain slices.
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• Effects of TND1128 (a 5-deazaflavin derivative), with self-redox ability, as a mitochondria activator on the mouse brain slice and its comparison with b-NMN.
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• Studies designed to demonstrate improvement in cognitive functions including attention have deployed a large variety of approaches that can be categorized as pharmaceutical. (2023)
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AC-11® (Uncaria tomentosa) & DNA Repair

• Introduction of Apoptosis and Inhibition of Proliferation in Human Tumor Cells Treated with Extracts of Uncaria tomentosa.
  (Sheng, Pero, Amiri, Bryngelsson – Anticancer Research 1998)
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• Enhanced DNA repair, immune function and reduced toxicity of ac-11® (CMED-100®), a novel aqueous extract from Uncaria tomentosa.
  (Sheng, Bryngelsson, Pero – Journal of Ethnopharmacology 1999)
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• Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa.
  (Shen, Pero, Wagner – Phytomedicine 2000)
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• DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study.
  (Sheng, Homgren, Pero – 2001)
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• Serum Thiols as a Surrogate Estimate of DNA Repair Correlates to Mammalian Life Span.
  (Pero, Hoppe, Sheng – Journal of Anti-aging Medicine 2000)
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• ac-11® and NF-KB-inhibition…an additional pathway for why ac-11® improves our natural DNA repair processes.
  (In-house data 2005; summary 2012)
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• Surrogate Indication of DNA Repair in Serum After Long Term Chiropractic Intervention – Retrospective Study.
  (Campbell, Kent, Bane, Amiri, Pero – Journal Vertebral Subluxation Res. 2005)
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• Brunswick Labs, Certificate of Analysis, ORAC Value ac-11®
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• Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements.
  (Pero, Amiri, Sheng, Welther, Rich – Phytomedicine 2005)
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• ac-11® claims substantiation document.
  (Zwiren 2010)
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• BIO-EC: Protection and preventive activity of ac-11® after UV irradiation and anti-aging activity on human skin explants maintained in survival. (2008)
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